vinca alkaloids sentence in Hindi
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- Vincamone is a vinca alkaloid and a metabolite of vincamine.
- In contrast to colchine, vinca alkaloids bind to the microtubule directly.
- L . ) . these are called vinca alkaloids.
- The original vinca alkaloids are completely natural chemicals that include vincristine and vinblastine.
- The vinca alkaloids and anthracyclines have been used most commonly in ECD treatment.
- Vinca alkaloids are used in chemotherapy for cancer.
- This is because vinca alkaloids are rapidly deactivated in myeloid cells by their enzyme myeloperoxidase.
- Minor vinca alkaloids include minovincine, methoxyminovincine, minovincinine, vincadifformine, desoxyvincaminol, and vincamajine.
- Vinca alkaloids are now produced synthetically and used as drugs in cancer therapy and as immunosuppressive drugs.
- For example, the vinca alkaloids and taxanes selectively bind and inhibit microtubules, leading to cell cycle arrest.
- Following the success of these drugs, semi-synthetic vinca alkaloids were produced : vinorelbine, vindesine, and vinflunine.
- The vinca alkaloids thus prevent microtubule " polymerization ", as opposed to the mechanism of action of taxanes.
- It is an vinca alkaloid obtained from " Rauwolfia serpentina " and other species of " Rauwolfia ".
- Her most notable work includes research on vinca alkaloids, and the development of anti-epileptic and anti-malarial drugs.
- The Vinca alkaloids bind to the ?-subunit of tubulin dimers at a distinct region called the Vinca-binding domain.
- These include paclitaxel, colchicine, and the vinca alkaloids, each of which have a distinct binding site on ?-tubulin.
- Vinca alkaloids are derived from the Madagascar periwinkle, " Catharanthus roseus " ( formerly known as " Vinca rosea " ).
- One class of inhibitors operate by inhibiting polymerization of tubulin to form microtubules and are called polymerization inhibitors like the colchine analogues and the vinca alkaloids.
- B ) Vinca alkaloids binding site, includes vinblastine, vincristine, vinorelbine, vinfluine, dolastatins, halichondrins, hemiasterlins, cryptophysin 52, etc.
- It has anti-microtubule activity, and its mechanism is similar to that of vinca alkaloids in that they bind to tubulin, inhibiting microtubule formation.
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